Bisphenol A exposure is associated with in vivo estrogenic gene expression in adults.

ABSTRACT:

Background

Bisphenol A (BPA) is a synthetic estrogen commonly used in polycarbonate plastic and resin-lined food and beverage containers. Exposure of animal and cell models to doses of BPA below the recommended tolerable daily intake (TDI) of 50 μg/kg/day have been shown to alter specific estrogen-responsive gene expression, but this has not previously been shown in humans.

Objective

We investigated associations between BPA exposure and in vivo estrogenic gene expression in humans.

Methods

We studied 96 adult men from the InCHIANTI population study and examined in vivo expression of six estrogen receptor, estrogen-related receptor, and androgen receptor genes in peripheral blood leukocytes.

Results

The geometric mean urinary BPA concentration was 3.65 ng/mL [95

SUBMITTER: Melzer D 

PROVIDER: S-EPMC3261992 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature