Sarcoidosis blood transcriptome reflects lung inflammation and overlaps with tuberculosis.

ABSTRACT:

Rationale

Sarcoidosis is a granulomatous disease of unknown etiology, although M. tuberculosis may play a role in the pathogenesis. The traditional view holds that inflammation in sarcoidosis is compartmentalized to involved organs.

Objectives

To determine whether whole blood gene expression signatures reflect inflammatory pathways in the lung in sarcoidosis and whether these signatures overlap with tuberculosis.

Methods

We analyzed transcriptomic data from blood and lung biopsies in sarcoidosis and compared these profiles with blood transcriptomic data from tuberculosis and other diseases.

Measurements and main results

Applying machine learning algorithms to blood gene expression data, we built a classifier that distinguished sarcoidosis from health in derivat

SUBMITTER: Koth LL 

PROVIDER: S-EPMC3262024 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature