Gastroesophageal reflux therapy is associated with longer survival in patients with idiopathic pulmonary fibrosis.

ABSTRACT:

Rationale

Gastroesophageal reflux (GER) is highly prevalent in patients with idiopathic pulmonary fibrosis (IPF). Chronic microaspiration secondary to GER may play a role in the pathogenesis and natural history of IPF.

Objectives

To investigate the relationship between GER-related variables and survival time in patients with IPF.

Methods

Regression analysis was used to investigate the relationship between GER-related variables and survival time in a retrospectively identified cohort of patients with well-characterized IPF from two academic medical centers.

Measurements and main results

Two hundred four patients were identified for inclusion. GER-related variables were common in this cohort: reported symptoms of GER (34%), a history of GER disease (45%), reporte

SUBMITTER: Lee JS 

PROVIDER: S-EPMC3262030 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature