Peripheral blood proteins predict mortality in idiopathic pulmonary fibrosis.

ABSTRACT:

Rationale

Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease of unknown etiology with a variable and unpredictable course.

Objectives

The aim of this study was to identify and validate plasma proteins that are predictive of outcome in IPF.

Methods

Plasma samples were available for 241 patients with IPF (140 derivation and 101 validation). In the derivation cohort, concentrations of 92 proteins were analyzed using a multiplex bead-based immunoassay and concentrations of matrix metalloproteinase (MMP)-7, MMP-1, and surfactant protein D were assessed by ELISA. In the validation cohort concentrations of intercellular adhesion molecule (ICAM)-1, IL-8, and vascular cell adhesion molecule (VCAM)-1 were assessed by bead-based multiplex assay, and S100A12 and MMP-7 b

SUBMITTER: Richards TJ 

PROVIDER: S-EPMC3262037 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature