Arteriolar function in visceral adipose tissue is impaired in human obesity.

ABSTRACT:

Objective

The purpose of this study was to characterize the relationship between adipose tissue phenotype and depot-specific microvascular function in fat.

Methods and results

In 30 obese subjects (age 42±11 years, body mass index 46±11 kg/m(2)) undergoing bariatric surgery, we intraoperatively collected visceral and subcutaneous adipose tissue and characterized depot-specific adipose phenotypes. We assessed vasomotor function of the adipose microvasculature using videomicroscopy of small arterioles (75-250 μm) isolated from different fat compartments. Endothelium-dependent, acetylcholine-mediated vasodilation was severely impaired in visceral arterioles, compared to the subcutaneous depot (P<0.001 by ANOVA). Nonendothelium dependent responses to papaverine and nitroprusside

SUBMITTER: Farb MG 

PROVIDER: S-EPMC3262114 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature