Clinical and genetic association of serum ceruloplasmin with cardiovascular risk.

ABSTRACT:

Objective

Ceruloplasmin (Cp) is an acute-phase reactant that is increased in inflammatory diseases and in acute coronary syndromes. Cp has recently been shown to possess nitric oxide (NO) oxidase catalytic activity, but its impact on long-term cardiovascular outcomes in stable cardiac patients has not been explored.

Methods and results

We examined serum Cp levels and their relationship with incident major adverse cardiovascular events (MACE; death, myocardial infarction [MI], stroke) over 3-year follow-up in 4177 patients undergoing elective coronary angiography. We also carried out a genome-wide association study to identify the genetic determinants of serum Cp levels and evaluate their relationship to prevalent and incident cardiovascular risk. In our cohort (age 63±11 yea

SUBMITTER: Tang WH 

PROVIDER: S-EPMC3262121 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature