Transglutaminase 2 facilitates the distant hematogenous metastasis of breast cancer by modulating interleukin-6 in cancer cells.

ABSTRACT:

Introduction

Inflammation has been implicated in cancer aggressiveness. As transglutaminase 2 (TG2), which has been associated with inflammatory signaling, has been suggested to play a role in tumor behavior, we propose that TG2 may be an important linker inducing interleukin (IL)-6-mediated cancer-cell aggressiveness, including distant hematogenous metastasis.

Methods

To investigate the role for TG2 and IL-6, TG2-knocked-down and IL-6-knocked-down cancer cells were generated by using shRNA. Human breast cancer cell xenograft model in highly immunocompromised mice and human advanced breast cancer primary tumor tissue microarrays were used in this study.

Results

IL-6 production in human breast cancer cells was dependent on their TG2 expression level. In vitro tumor-sph

SUBMITTER: Oh K 

PROVIDER: S-EPMC3262209 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature