Regulatory coordination of clustered microRNAs based on microRNA-transcription factor regulatory network.

ABSTRACT:

Background

MicroRNA (miRNA) is a class of small RNAs of ~22nt which play essential roles in many crucial biological processes and numerous human diseases at post-transcriptional level of gene expression. It has been revealed that miRNA genes tend to be clustered, and the miRNAs organized into one cluster are usually transcribed coordinately. This implies a coordinated regulation mode exerted by clustered miRNAs. However, how the clustered miRNAs coordinate their regulations on large scale gene expression is still unclear.

Results

We constructed the miRNA-transcription factor regulatory network that contains the interactions between transcription factors (TFs), miRNAs and non-TF protein-coding genes, and made a genome-wide study on the regulatory coordination of clustered miR

SUBMITTER: Wang J 

PROVIDER: S-EPMC3262773 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature