RNA-seq based transcriptional map of bovine respiratory disease pathogen "Histophilus somni 2336".

ABSTRACT: Genome structural annotation, i.e., identification and demarcation of the boundaries for all the functional elements in a genome (e.g., genes, non-coding RNAs, proteins and regulatory elements), is a prerequisite for systems level analysis. Current genome annotation programs do not identify all of the functional elements of the genome, especially small non-coding RNAs (sRNAs). Whole genome transcriptome analysis is a complementary method to identify "novel" genes, small RNAs, regulatory regions, and operon structures, thus improving the structural annotation in bacteria. In particular, the identification of non-coding RNAs has revealed their widespread occurrence and functional importance in gene regulation, stress and virulence. However, very little is known about non-coding transcripts i

SUBMITTER: Kumar R 

PROVIDER: S-EPMC3262788 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature