Synthesis of C-glycoside analogues of α-galactosylceramide via linear allylic C-H oxidation and allyl cyanate to isocyanate rearrangement.

ABSTRACT: C-Glycoside analogues of α-galactosylceramide were synthesized in which several significant modifications known to promote Th-1 cytokine production were included. The key transformations include C-H oxidation, Sharpless asymmetric epoxidation, olefin cross metathesis, and an allyl cyanate to isocyanate rearrangement.

SUBMITTER: Liu Z 

PROVIDER: S-EPMC3263403 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature