Genetic risk assessment of type 2 diabetes-associated polymorphisms in African Americans.

ABSTRACT:

Objective

Multiple single nucleotide polymorphisms (SNPs) associated with type 2 diabetes (T2D) susceptibility have been identified in predominantly European-derived populations. These SNPs have not been extensively investigated for individual and cumulative effects on T2D risk in African Americans.

Research design and methods

Seventeen index T2D risk variants were genotyped in 2,652 African American case subjects with T2D and 1,393 nondiabetic control subjects. Individual SNPs and cumulative risk allele loads were assessed for association with risk for T2D. Cumulative risk was assessed by counting risk alleles and evaluating the difference in cumulative risk scores between case subjects and control subjects. A second analysis weighted risk scores (ln [OR]) based on previous

SUBMITTER: Cooke JN 

PROVIDER: S-EPMC3263882 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature