The impact of frequent and unrecognized hypoglycemia on mortality in the ACCORD study.

ABSTRACT:

Objective

The aim of this study was to examine the relationship between frequent and unrecognized hypoglycemia and mortality in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study cohort.

Research design and methods

A total of 10,096 ACCORD study participants with follow-up for both hypoglycemia and mortality were included. Hazard ratios (95% CIs) relating the risk of death to the updated annualized number of hypoglycemic episodes and the updated annualized number of intervals with unrecognized hypoglycemia were obtained using Cox proportional hazards regression models, allowing for these hypoglycemia variables as time-dependent covariates and controlling for the baseline covariates.

Results

Participants in the intensive group reported a mean of 1.06

SUBMITTER: Seaquist ER 

PROVIDER: S-EPMC3263892 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature