Two patterns of adipokine and other biomarker dynamics in a long-term weight loss intervention.

ABSTRACT:

Objective

Long-term dietary intervention frequently induces a rapid weight decline followed by weight stabilization/regain. Here, we sought to identify adipokine biomarkers that may reflect continued beneficial effects of dieting despite partial weight regain.

Research design and methods

We analyzed the dynamics of fasting serum levels of 12 traditional metabolic biomarkers and novel adipokines among 322 participants in the 2-year Dietary Intervention Randomized Controlled Trial (DIRECT) of low-fat, Mediterranean, or low-carbohydrate diets for weight loss.

Results

We identified two distinct patterns: Pattern A includes biomarkers (insulin, triglycerides, leptin, chemerin, monocyte chemoattractant protein 1, and retinol-binding protein 4) whose dynamics tightly corresp

SUBMITTER: Bluher M 

PROVIDER: S-EPMC3263919 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature