The Vibrio cholerae mannitol transporter is regulated posttranscriptionally by the MtlS small regulatory RNA.

ABSTRACT: Vibrio cholerae continues to pose a health threat in many developing nations and regions of the world struck by natural disasters. It is a pathogen that rapidly adapts to aquatic environments and the human small intestine. Small regulatory RNAs (sRNAs) may contribute to this adaptability. Specifically, the mannitol operon sRNA (MtlS sRNA; previously designated the IGR7 sRNA) is transcribed antisense to the 5' untranslated region of the mtl operon, encoding the mannitol-specific phosphotransferase system. Mannitol is a six-carbon sugar alcohol that accumulates in the human small intestine, the primary site of V. cholerae colonization. To better understand the V. cholerae mtl operon at a molecular level, we investigated mtlA expression in the presence of various carbon sources and the role o

SUBMITTER: Mustachio LM 

PROVIDER: S-EPMC3264093 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature