Inactivation of the lipopeptide antibiotic daptomycin by hydrolytic mechanisms.

ABSTRACT: The lipopeptide daptomycin is a member of the newest FDA-approved antimicrobial class, exhibiting potency against a broad range of Gram-positive pathogens with only rare incidences of clinical resistance. Environmental bacteria harbor an abundance of resistance determinants orthologous to those in pathogens and thus may serve as an early-warning system for future clinical emergence. A collection of morphologically diverse environmental actinomycetes demonstrating unprecedented frequencies of daptomycin resistance and high levels of resistance by antibiotic inactivation was characterized to elucidate modes of drug inactivation. In vivo studies revealed that hydrolysis plays a key role, resulting in one or both of the following structural modifications: ring hydrolysis resulting in lineariza

SUBMITTER: D'Costa VM 

PROVIDER: S-EPMC3264212 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature