Effects of BRCA2 deficiency on telomere recombination in non-ALT and ALT cells.

ABSTRACT:

Background

Recent studies suggest that BRCA2 affects telomere maintenance. Interestingly, anti cancer treatments that involve BRCA2 and telomerase individually are currently being explored. In the light of the above recent studies their combinatorial targeting may be justified in the development of future treatments. In order to investigate effects of BRCA2 that can be explored for this combinatorial targeting we focused on the analysis of recombination rates at telomeres by monitoring T-SCEs (Telomere Sister Chromatid Exchanges).

Results

We observed a significant increase in T-SCE frequencies in four BRCA2 defective human cell lines thus suggesting that BRCA2 suppresses recombination at telomeres. To test this hypothesis further we analyzed T-SCE frequencies in a set of Chi

SUBMITTER: Sapir E 

PROVIDER: S-EPMC3264516 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature