Association of polymorphisms in survivin gene with the risk of hepatocellular carcinoma in Chinese han population: a case control study.

ABSTRACT:

Background

Survivin, one of the strongest apoptosis inhibitors, plays a critical role in the development and progression of hepatocellular carcinoma (HCC). By comparison, relatively little is known about the effect of survivin gene polymorphisms on HCC susceptibility. Our study aimed to investigate the association of survivin gene polymorphisms with the risk of HCC in Chinese han population.

Methods

A case-control study was conducted in Chinese han population consisting of 178 HCC cases and 196 cancer-free controls. Information on demographic data and related risk factors was collected for all subjects. Polymorphisms of the survivin gene, including three loci of rs8073069, rs9904341 and rs1042489, were selected and genotyped by a polymerase chain reaction- restriction fragme

SUBMITTER: Li Y 

PROVIDER: S-EPMC3264525 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature