Serotonin transporter polymorphism modulates N-back task performance and fMRI BOLD signal intensity in healthy women.

ABSTRACT:

Context

Exploring intermediate phenotypes within the human brain's functional and structural circuitry is a promising approach to explain the relative contributions of genetics, complex behaviors and neural mechanisms in the development of major depressive disorder (MDD). The polymorphic region 5-HTTLPR in the serotonin transporter gene (SLC6A4) has been shown to modulate MDD risk, but the neural underpinnings are incompletely understood.

Objective

37 right handed healthy women between 21 and 61 years of age were invited to participate in an fMRI modified n-back study. The functional polymorphism 5-HTTLPR located in the promoter region of the SLC6A4 gene was genotyped using polymerase chain reaction (PCR).

Results

Short 5-HTTLPR allele carriers showed more blood-oxyge

SUBMITTER: Jonassen R 

PROVIDER: S-EPMC3264612 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature