Cognitive-behavioral stress management reverses anxiety-related leukocyte transcriptional dynamics.

ABSTRACT:

Background

Chronic threat and anxiety are associated with pro-inflammatory transcriptional profiles in circulating leukocytes, but the causal direction of that relationship has not been established. This study tested whether a cognitive-behavioral stress management (CBSM) intervention targeting negative affect and cognition might counteract anxiety-related transcriptional alterations in people confronting a major medical threat.

Methods

One hundred ninety-nine women undergoing primary treatment of stage 0-III breast cancer were randomized to a 10-week CBSM protocol or an active control condition. Seventy-nine provided peripheral blood leukocyte samples for genome-wide transcriptional profiling and bioinformatic analyses at baseline, 6-month, and 12-month follow-ups.

Resul

SUBMITTER: Antoni MH 

PROVIDER: S-EPMC3264698 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature