Dysbalance of cortical inhibition and excitation in abstinent cocaine-dependent patients.

ABSTRACT: The effects of chronic cocaine dependence on cortical inhibitory/excitatory processes are not well characterized. Employing transcranial magnetic stimulation measures of motor cortical excitability, we have previously reported an elevation of motor threshold (MT) suggesting reduced excitability and an increased long-interval intracortical facilitation (LICF) suggesting increased excitability. In the current study, we used an expanded battery of TMS cortical excitability measures to further examine motor cortex excitability in a larger sample of well-characterized and closely monitored for drug use, abstinent cocaine-dependent subjects (N = 52) and healthy controls (N = 42). Furthermore, coil-to-cortex distance was assessed in a subsample of both groups. We verified that long-interval intra

SUBMITTER: Gjini K 

PROVIDER: S-EPMC3264814 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature