Anatomy and physiology predict response to motor cortex stimulation after stroke.

ABSTRACT:

Objectives

Preclinical studies found that epidural motor cortex stimulation improved motor deficits after stroke, but a phase III trial in humans did not corroborate these results. The current retrospective analysis examined subjects randomized to stimulation in order to identify features distinguishing responders from nonresponders.

Methods

Anatomic (MRI measures of gray matter thickness and of white matter tract injury) and physiologic methods (motor evoked responses) were examined as predictors of treatment response.

Results

Among 60 subjects randomized to cortical stimulation, both anatomic and physiologic measures at baseline predicted behavioral response to therapy. Anatomically, those achieving the primary efficacy endpoint had a smaller fraction of the cortico

SUBMITTER: Nouri S 

PROVIDER: S-EPMC3265049 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature