Synthetic Studies Towards MPC1001: Preparation of a β-hydroxyl-Tyrosine Derivative.

ABSTRACT: A procedure for the asymmetric synthesis of a novel β-hydroxy-α-amino acid deriverative to be used in the preparation of the natural product MPC1001 and analogs has been developed. The amino acid was efficiently prepared in six steps via a Mukaiyama aldol reaction via a diphenyloxazinone and 3-bromo-4-methoxybenzaldehyde.

SUBMITTER: Schuber PT 

PROVIDER: S-EPMC3265114 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature