Dialysate sodium concentration and the association with interdialytic weight gain, hospitalization, and mortality.

ABSTRACT:

Background and objectives

Recommendations to decrease the dialysate sodium (DNa) prescription demand analyses of patient outcomes. We analyzed morbidity and mortality at various levels of DNa, simultaneously accounting for interdialytic weight gain (IDWG) and for the mortality risk associated with lower predialysis serum sodium (SNa) levels.

Design, setting, participants, & measurements

We used multiply-adjusted linear mixed models to evaluate the magnitude of IDWG and Cox proportional hazards models to assess hospitalizations and deaths in 29,593 patients from the Dialysis Outcomes and Practice Patterns Study with baseline DNa and SNa as predictors, categorized according to lowest to highest levels.

Results

IDWG increased with higher DNa across all SNa categories, by

SUBMITTER: Hecking M 

PROVIDER: S-EPMC3265348 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature