A reported "new synthesis of lysergic acid" yields only the derailment product: methyl 5-methoxy-4,5-dihydroindolo[4,3-f,g]quinoline-9-carboxylate.

ABSTRACT: The treatment of ethyl 6-formyl-5-(1H-indol-4-yl)pyridine-3-carboxylate (2) with NaOMe or NaOH in methanol solution at room temperature under the reported reaction conditions afforded solely product 4 in 80% yield, rather than anticipated product 3.

SUBMITTER: Bekkam M 

PROVIDER: S-EPMC3265357 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature