Functional categories associated with clusters of genes that are co-expressed across the NCI-60 cancer cell lines.

ABSTRACT:

Background

The NCI-60 is a panel of 60 diverse human cancer cell lines used by the U.S. National Cancer Institute to screen compounds for anticancer activity. In the current study, gene expression levels from five platforms were integrated to yield a single composite transcriptome profile. The comprehensive and reliable nature of that dataset allows us to study gene co-expression across cancer cell lines.

Methodology/principal findings

Hierarchical clustering revealed numerous clusters of genes in which the genes co-vary across the NCI-60. To determine functional categorization associated with each cluster, we used the Gene Ontology (GO) Consortium database and the GoMiner tool. GO maps genes to hierarchically-organized biological process categories. GoMiner can leverage GO

SUBMITTER: Zeeberg BR 

PROVIDER: S-EPMC3265467 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature