Sequencing and characterization of Varicella-zoster virus vaccine strain SuduVax.

ABSTRACT:

Background

Varicella-zoster virus (VZV) causes chickenpox in children and shingles in older people. Currently, live attenuated vaccines based on the Oka strain are available worldwide. In Korea, an attenuated VZV vaccine has been developed from a Korean isolate and has been commercially available since 1994. Despite this long history of use, the mechanism for the attenuation of the vaccine strain is still elusive. We attempted to understand the molecular basis of attenuation mechanism by full genome sequencing and comparative genomic analyses of the Korean vaccine strain SuduVax.

Results

SuduVax was found to contain a genome that was 124,759 bp and possessed 74 open reading frames (ORFs). SuduVax was genetically most close to Oka strains and these Korean-Japanese strains for

SUBMITTER: Kim JI 

PROVIDER: S-EPMC3265557 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature