Transition to collateral flow after arterial occlusion predisposes to cerebral venous steal.

ABSTRACT:

Background and purpose

Stroke-related tissue pressure increase in the core and penumbra determines regional cerebral perfusion pressure (rCPP) defined as a difference between local inflow pressure and venous or tissue pressure, whichever is higher. We previously showed that venous pressure reduction below the pressure in the core causes blood flow diversion-cerebral venous steal. Now we investigated how transition to collateral circulation after complete arterial occlusion affects rCPP distribution.

Methods

We modified parallel Starling resistor model to simulate transition to collateral inflow after complete main stem occlusion. We decreased venous pressure from the arterial pressure to zero and investigated how arterial and venous pressure elevation augments rCPP.

Resul

SUBMITTER: Pranevicius O 

PROVIDER: S-EPMC3265650 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature