Chromosome 20 shows linkage with DSM-IV nicotine dependence in Finnish adult smokers.

ABSTRACT:

Introduction

Chromosome 20 has previously been associated with nicotine dependence (ND) and smoking cessation. Our aim was to replicate and extend these findings.

Methods

First, a total of 759 subjects belonging to 206 Finnish families were genotyped with 18 microsatellite markers residing on chromosome 20, in order to replicate previous linkage findings. Then, the replication data were combined to an existing whole-genome linkage data resulting in a total of 1,302 genotyped subjects from 357 families. ND diagnosed by DSM-IV criteria, the Fagerström Test for Nicotine Dependence (FTND) score, and the lifetime maximum number of cigarettes smoked within a 24-hr period (MaxCigs24) were used as phenotypes in the nonparametric linkage analyses.

Results

We replicated previou

SUBMITTER: Keskitalo-Vuokko K 

PROVIDER: S-EPMC3265743 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature