Functional promoter -31G>C variant in survivin gene is associated with risk and progression of renal cell cancer in a Chinese population.

ABSTRACT:

Background

Survivin is an inhibitor of apoptosis protein and is involved in the occurrence and progression of human malignancies. Recently, a functional polymorphism (-31G>C, rs9904341) in the promoter of survivin has been shown to influence its expression and confer susceptibility to different types of cancer. The present study was aimed to investigate whether the polymorphism also influences susceptibility and progression of renal cell cancer (RCC) in a Chinese population.

Methods

We genotyped this polymorphism using the TaqMan assay in a case-control study comprised of 710 RCC patients and 760 controls. The logistic regression was used to assess the genetic association with occurrence and progression of RCC.

Results

Compared with the genotypes containing G allele (

SUBMITTER: Qin C 

PROVIDER: S-EPMC3266235 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature