Molecular structure and target recognition of neuronal calcium sensor proteins.

ABSTRACT:

Background

Neuronal calcium sensor (NCS) proteins, a sub-branch of the calmodulin superfamily, are expressed in the brain and retina where they transduce calcium signals and are genetically linked to degenerative diseases. The amino acid sequences of NCS proteins are highly conserved but their physiological functions are quite distinct. Retinal recoverin and guanylate cyclase activating proteins (GCAPs) both serve as calcium sensors in retinal rod cells, neuronal frequenin (NCS1) modulate synaptic activity and neuronal secretion, K+ channel interacting proteins (KChIPs) regulate ion channels to control neuronal excitability, and DREAM (KChIP3) is a transcriptional repressor that regulates neuronal gene expression.

Scope of review

Here we review the molecular structures of my

SUBMITTER: Ames JB 

PROVIDER: S-EPMC3266469 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature