Ontology highlight
ABSTRACT:
SUBMITTER: Lee KH
PROVIDER: S-EPMC3266596 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Molecular and cellular biology 20111128 3
The mouse PERIOD1 (mPER1) protein, along with other clock proteins, plays a crucial role in the maintenance of circadian rhythms. mPER1 also provides an important link between the circadian system and the cell cycle system. Here we show that the circadian expression of mPER1 is regulated by rhythmic translational control of mPer1 mRNA together with transcriptional modulation. This time-dependent translation was controlled by an internal ribosomal entry site (IRES) element in the 5' untranslated ...[more]