Novel transporter required for biogenesis of cbb3-type cytochrome c oxidase in Rhodobacter capsulatus.

ABSTRACT:

Unlabelled

The acquisition, delivery, and incorporation of metals into their respective metalloproteins are important cellular processes. These processes are tightly controlled in order to prevent exposure of cells to free-metal concentrations that could yield oxidative damage. Copper (Cu) is one such metal that is required as a cofactor in a variety of proteins. However, when present in excessive amounts, Cu is toxic due to its oxidative capability. Cytochrome c oxidases (Coxs) are among the metalloproteins whose assembly and activity require the presence of Cu in their catalytic subunits. In this study, we focused on the acquisition of Cu for incorporation into the heme-Cu binuclear center of the cbb(3)-type Cox (cbb(3)-Cox) in the facultative phototroph Rhodobacter capsulatus. G

SUBMITTER: Ekici S 

PROVIDER: S-EPMC3266609 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature