Notch pathway regulation of neural crest cell development in vivo.

ABSTRACT:

Background

The function of Notch signaling in murine neural crest-derived cell lineages in vivo was examined.

Results

Conditional gain (Wnt1Cre;Rosa(Notch)) or loss (Wnt1Cre;RBP-J(f/f)) of Notch signaling in neural crest cells (NCCs) in vivo results in craniofacial, cardiac, and trunk abnormalities. Severe craniofacial malformations are apparent in Wnt1Cre;Rosa(Notch) embryos, while less severe skull abnormalities are evident in Wnt1Cre;RBP-J(f/f) mice. Deficient cardiac neural crest migration, resulting in cardiac outflow tract malformations, occurs with increased or decreased Notch signaling in NCCs. Smooth muscle cell differentiation also is impaired in pharyngeal NCC derivatives in both Wnt1Cre;Rosa(Notch) and Wnt1Cre;RBP-J(f/f) embryos. Neurogenesis is absent and glioge

SUBMITTER: Mead TJ 

PROVIDER: S-EPMC3266628 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature