Primary motor cortex in stroke: a functional MRI-guided proton MR spectroscopic study.

ABSTRACT:

Background and purpose

Our goal was to investigate whether certain metabolites, specific to neurons, glial cells, or the neuronal-glial neurotransmission system, in primary motor cortices (M1), are altered and correlated with clinical motor severity in chronic stroke.

Methods

Fourteen survivors of a single ischemic stroke located outside the M1 and 14 age-matched healthy control subjects were included. At >6 months after stroke, N-acetylaspartate, myo-inositol, and glutamate/glutamine were measured using proton magnetic resonance spectroscopic imaging (in-plane resolution=5×5 mm(2)) in radiologically normal-appearing gray matter of the hand representation area, identified by functional MRI, in each M1. Metabolite concentrations and analyses of metabolite correlations within

SUBMITTER: Cirstea CM 

PROVIDER: S-EPMC3266712 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature