USF-1 is critical for maintaining genome integrity in response to UV-induced DNA photolesions.

ABSTRACT: An important function of all organisms is to ensure that their genetic material remains intact and unaltered through generations. This is an extremely challenging task since the cell's DNA is constantly under assault by endogenous and environmental agents. To protect against this, cells have evolved effective mechanisms to recognize DNA damage, signal its presence, and mediate its repair. While these responses are expected to be highly regulated because they are critical to avoid human diseases, very little is known about the regulation of the expression of genes involved in mediating their effects. The Nucleotide Excision Repair (NER) is the major DNA-repair process involved in the recognition and removal of UV-mediated DNA damage. Here we use a combination of in vitro and in vivo assays

SUBMITTER: Baron Y 

PROVIDER: S-EPMC3266871 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature