Genomic and SNP analyses demonstrate a distant separation of the hospital and community-associated clades of Enterococcus faecium.

ABSTRACT: Recent studies have pointed to the existence of two subpopulations of Enterococcus faecium, one containing primarily commensal/community-associated (CA) strains and one that contains most clinical or hospital-associated (HA) strains, including those classified by multi-locus sequence typing (MLST) as belonging to the CC17 group. The HA subpopulation more frequently has IS16, pathogenicity island(s), and plasmids or genes associated with antibiotic resistance, colonization, and/or virulence. Supporting the two clades concept, we previously found a 3-10% difference between four genes from HA-clade strains vs. CA-clade strains, including 5% difference between pbp5-R of ampicillin-resistant, HA strains and pbp5-S of ampicillin-sensitive, CA strains. To further investigate the core genome of th

SUBMITTER: Galloway-Pena J 

PROVIDER: S-EPMC3266884 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature