Faster HIV-1 disease progression among Brazilian individuals recently infected with CXCR4-utilizing strains.

ABSTRACT:

Introduction

Primary HIV infection is usually caused by R5 viruses, and there is an association between the emergence of CCXR4-utilizing strains and faster disease progression. We characterized HIV-1 from a cohort of recently infected individuals in Brazil, predicted the virus's co-receptor use based on the env genotype and attempted to correlate virus profiles with disease progression.

Methods

A total of 72 recently infected HIV patients were recruited based on the Serologic Testing Algorithm for Recent HIV Seroconversion and were followed every three to four months for up to 78 weeks. The HIV-1 V3 region was characterized by sequencing nine to twelve weeks after enrollment. Disease progression was characterized by CD4+ T-cell count decline to levels consistently below 350

SUBMITTER: Sucupira MC 

PROVIDER: S-EPMC3266896 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature