SPPS: a sequence-based method for predicting probability of protein-protein interaction partners.

ABSTRACT:

Background

The molecular network sustained by different types of interactions among proteins is widely manifested as the fundamental driving force of cellular operations. Many biological functions are determined by the crosstalk between proteins rather than by the characteristics of their individual components. Thus, the searches for protein partners in global networks are imperative when attempting to address the principles of biology.

Results

We have developed a web-based tool "Sequence-based Protein Partners Search" (SPPS) to explore interacting partners of proteins, by searching over a large repertoire of proteins across many species. SPPS provides a database containing more than 60,000 protein sequences with annotations and a protein-partner search engine in two modes (

SUBMITTER: Liu X 

PROVIDER: S-EPMC3266917 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature