Effects of a short course of inhaled corticosteroids in noneosinophilic asthmatic subjects.

ABSTRACT:

Background

Noneosinophilic asthma has been regarded as a distinct phenotype characterized by a poor response to inhaled corticosteroids (ICS).

Objective

To determine whether noneosinophilic, steroid-naive asthmatic subjects show an improvement in asthma control, asthma symptoms and spirometry after four weeks of treatment with ICS, and whether they further benefit from the addition of a long-acting beta-2 agonists to ICS.

Methods

A randomized, double-blind, placebo-controlled, multicentre study comparing the efficacy of placebo versus inhaled fluticasone propionate 250 mcg twice daily for four weeks in mildly uncontrolled, steroid-naive asthmatic subjects with a sputum eosinophil count of 2% or less. This was followed by an open-label, four-week treatment period with

SUBMITTER: Lemiere C 

PROVIDER: S-EPMC3267606 | biostudies-literature | 2011 Sep-Oct

REPOSITORIES: biostudies-literature