Myocardial alternative RNA splicing and gene expression profiling in early stage hypoplastic left heart syndrome.

ABSTRACT: Hypoplastic Left Heart Syndrome (HLHS) is a congenital defect characterized by underdevelopment of the left ventricle and pathological compensation of the right ventricle. If untreated, HLHS is invariably lethal due to the extensive increase in right ventricular workload and eventual failure. Despite the clinical significance, little is known about the molecular pathobiological state of HLHS. Splicing of mRNA transcripts is an important regulatory mechanism of gene expression. Tissue specific alterations of this process have been associated with several cardiac diseases, however, transcriptional signature profiles related to HLHS are unknown. In this study, we performed genome-wide exon array analysis to determine differentially expressed genes and alternatively spliced transcripts in the

SUBMITTER: Ricci M 

PROVIDER: S-EPMC3267718 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature