Binding of more than one Tva800 molecule is required for ASLV-A entry.

ABSTRACT:

Background

Understanding the mechanism by which viruses enter their target cell is an essential part of understanding their infectious cycle. Previous studies have focussed on the multiplicity of viral envelope proteins that need to bind to their cognate receptor to initiate entry. Avian sarcoma and leukosis virus Envelope protein (ASLV Env) mediates entry via a receptor, Tva, which can be attached to the cell surface either by a phospholipid anchor (Tva800) or a transmembrane domain (Tva950). In these studies, we have now investigated the number of target receptors necessary for entry of ASLV Env-pseudotyped virions.

Results

Using titration and modelling experiments we provide evidence that binding of more than one receptor, probably two, is needed for entry of virions via

SUBMITTER: Gray ER 

PROVIDER: S-EPMC3267798 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature