Structural mass spectrometry: rapid methods for separation and analysis of peptide natural products.

ABSTRACT: A significant challenge in natural product discovery is the initial discrimination of discrete secondary metabolites alongside functionally similar primary metabolic cellular components within complex biological samples. A property that has yet to be fully exploited for natural product identification and characterization is the gas-phase collision cross section, or, more generally, the mobility-mass correlation. Peptide natural products possess many of the properties that distinguish natural products, as they are frequently characterized by a high degree of intramolecular bonding and possess extended and compact conformations among other structural modifications. This report describes a rapid structural mass spectrometry technique based on ion mobility-mass spectrometry for the comparison

SUBMITTER: Goodwin CR 

PROVIDER: S-EPMC3267852 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature