Familial clustering of epilepsy and behavioral disorders: evidence for a shared genetic basis.

ABSTRACT:

Purpose

To examine whether family history of unprovoked seizures is associated with behavioral disorders in epilepsy probands, thereby supporting the hypothesis of shared underlying genetic susceptibility to these disorders.

Methods

We conducted an analysis of the 308 probands with childhood onset epilepsy from the Connecticut Study of Epilepsy with information on first-degree family history of unprovoked seizures and of febrile seizures whose parents completed the Child Behavior Checklist (CBCL) at the 9-year follow-up. Clinical cutoffs for CBCL problem and Diagnostic and Statistical Manual of Mental Disorders (DSM)-Oriented scales were examined. The association between first-degree family history of unprovoked seizure and behavioral disorders was assessed separately in unc

SUBMITTER: Hesdorffer DC 

PROVIDER: S-EPMC3267857 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature