Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection.

ABSTRACT: Tuberculosis (TB) is a major public health problem. One-third of the world's population is estimated to be infected with Mycobacterium tuberculosis (MTB), the etiological agent causing TB, and active disease kills nearly 2 million individuals worldwide every year. Several lines of evidence indicate that interindividual variation in susceptibility to TB has a heritable component, yet we still know little about the underlying genetic architecture. To address this, we performed a genome-wide mapping study of loci that are associated with functional variation in immune response to MTB. Specifically, we characterized transcript and protein expression levels and mapped expression quantitative trait loci (eQTL) in primary dendritic cells (DCs) from 65 individuals, before and after infection with

SUBMITTER: Barreiro LB 

PROVIDER: S-EPMC3268270 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature