Genome-wide association study identifies PERLD1 as asthma candidate gene.

ABSTRACT:

Background

Recent genome-wide association studies (GWAS) for asthma have been successful in identifying novel associations which have been well replicated. The aim of this study is to identify the genetic variants that influence predisposition towards asthma in an ethnic Chinese population in Singapore using a GWAS approach.

Methods

A two-stage GWAS was performed in case samples with allergic asthma, and in control samples without asthma and atopy. In the discovery stage, 490 case and 490 control samples were analysed by pooled genotyping. Significant associations from the first stage were evaluated in a replication cohort of 521 case and 524 control samples in the second stage. The same 980 samples used in the discovery phase were also individually genotyped for purposes of

SUBMITTER: Anantharaman R 

PROVIDER: S-EPMC3268734 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature