Identification of novel loci for Alzheimer disease and replication of CLU, PICALM, and BIN1 in Caribbean Hispanic individuals.

ABSTRACT:

Objectives

To identify novel loci for late-onset Alzheimer disease (LOAD) in Caribbean Hispanic individuals and to replicate the findings in a publicly available data set from the National Institute on Aging Late-Onset Alzheimer's Disease Family Study.

Design

Nested case-control genome-wide association study.

Setting

The Washington Heights-Inwood Columbia Aging Project and the Estudio Familiar de Influencia Genetica de Alzheimer study.

Participants

Five hundred forty-nine affected and 544 unaffected individuals of Caribbean Hispanic ancestry.

Intervention

The Illumina HumanHap 650Y chip for genotyping.

Main outcome measure

Clinical diagnosis or pathologically confirmed diagnosis of LOAD.

Results

The strongest support for allelic association

SUBMITTER: Lee JH 

PROVIDER: S-EPMC3268783 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature