The transcription factor Sox11 promotes nerve regeneration through activation of the regeneration-associated gene Sprr1a.

ABSTRACT: Factors that enhance the intrinsic growth potential of adult neurons are key players in the successful repair and regeneration of neurons following injury. Injury-induced activation of transcription factors has a central role in this process because they regulate expression of regeneration-associated genes. Sox11 is a developmentally expressed transcription factor that is significantly induced in adult neurons in response to injury. Its function in injured neurons is however undefined. Here, we report studies that use herpes simplex virus (HSV)-vector-mediated expression of Sox11 in adult sensory neurons to assess the effect of Sox11 overexpression on neuron regeneration. Cultured mouse dorsal root ganglia (DRG) neurons transfected with HSV-Sox11 exhibited increased neurite elongation and

SUBMITTER: Jing X 

PROVIDER: S-EPMC3268837 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature