Evidence for gene-gene epistatic interactions among susceptibility loci for systemic lupus erythematosus.

ABSTRACT:

Objective

Several confirmed genetic susceptibility loci for lupus have been described. To date, no clear evidence for genetic epistasis in lupus has been established. The aim of this study was to test for gene-gene interactions in a number of known lupus susceptibility loci.

Methods

Eighteen single-nucleotide polymorphisms tagging independent and confirmed lupus susceptibility loci were genotyped in a set of 4,248 patients with lupus and 3,818 normal healthy control subjects of European descent. Epistasis was tested by a 2-step approach using both parametric and nonparametric methods. The false discovery rate (FDR) method was used to correct for multiple testing.

Results

We detected and confirmed gene-gene interactions between the HLA region and CTLA4, IRF5, and ITGAM

SUBMITTER: Hughes T 

PROVIDER: S-EPMC3268866 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature