The effect of chemotherapy on expression of folate receptor-alpha in ovarian cancer.

ABSTRACT:

Background

Folate receptor alpha (FR-α) has been identified as a potential target in ovarian cancer for diagnostic and therapeutic purposes, based on its overexpression in serous epithelial ovarian carcinoma. The effect of chemotherapy on FR-α expression may be important in the applicability of FR-α directed agents in the case of residual tumor tissue. The objective of this study was to assess FR-α expression in ovarian carcinoma and to evaluate whether FR-α expression is altered by chemotherapy.

Materials & methods

FR-α expression was analyzed by semi-quantitative scoring of immunohistochemical staining on tissue microarrays (TMAs) from a database containing 361 ovarian cancer tissue samples, of which 210 serous and 116 non-serous carcinoma (35 missing). Serous carcinoma sa

SUBMITTER: Crane LM 

PROVIDER: S-EPMC3268989 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature