Cytokine gene polymorphisms and the outcome of invasive candidiasis: a prospective cohort study.

ABSTRACT:

Background

 Candida bloodstream infections cause significant morbidity and mortality among hospitalized patients. Although clinical and microbiological factors affecting prognosis have been identified, the impact of genetic variation in the innate immune responses mediated by cytokines on outcomes of infection remains to be studied.

Methods

 A cohort of 338 candidemia patients and 351 noninfected controls were genotyped for single-nucleotide polymorphisms (SNPs) in 6 cytokine genes (IFNG, IL10, IL12B, IL18, IL1β, IL8) and 1 cytokine receptor gene (IL12RB1). The association of SNPs with both candidemia susceptibility and outcome were assessed. Concentrations of pro- and antiinflammatory cytokines were measured in in vitro peripheral blood mononuclear cell stimulation assays a

SUBMITTER: Johnson MD 

PROVIDER: S-EPMC3269308 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature